General Information:

Id: 218 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
BTO:0001279 spinal cord
article
Reference: Atkin JD et al.(2006) Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1 J. Biol. Chem. 281 [PMID: 16847061]

Interaction Information:

Comment Spinal cords of transgenic SOD1(G93A) mice and rats showed a significant upregulation of PDI and Erp57.
Formal Description
Interaction-ID: 875

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

P4HB

Drugbank entries Show/Hide entries for P4HB
Comment Spinal cords of transgenic SOD1(G93A) mice showed a significant upregulation of PDI and Erp57.
Formal Description
Interaction-ID: 876

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

PDIA3

Comment Spinal cord homogenates from transgenic SOD1(G93A) and wt mice at p120 (postnatal day) showed physical interaction between SOD1 and PDI.
Formal Description
Interaction-ID: 888

gene/protein mutant

SOD1-p.G93A

interacts (colocalizes) with

gene/protein

P4HB

Drugbank entries Show/Hide entries for P4HB
Comment SOD1(G93A) mice induced the upregulation of UPR markers PERK, ATF6, CHOP and IRE1 at postnatal day 90 (p90) and disease end stage p120.
Formal Description
Interaction-ID: 890

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

EIF2AK3

at stage p90 and disease end stage p120
Comment SOD1(G93A) mice induced the upregulation of UPR markers PERK, ATF6, CHOP and IRE1 at postnatal day 90 (p90) and disease end stage p120.
Formal Description
Interaction-ID: 891

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

ATF6

at stage p90 and disease end stage p120
Comment SOD1(G93A) mice induced the upregulation of UPR markers PERK, ATF6, CHOP and IRE1 at postnatal day 90 (p90) and disease end stage p120.
Formal Description
Interaction-ID: 892

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

DDIT3

at stage p90 and disease end stage p120
Comment SOD1(G93A) mice induced the upregulation of UPR markers PERK, ATF6, CHOP and IRE1 at postnatal day 90 (p90) and disease end stage p120.
Formal Description
Interaction-ID: 893

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

ERN1

at stage p90 and disease end stage p120
Drugbank entries Show/Hide entries for ERN1
Comment SOD1(G93A) mice induced the upregulation of the ER chaperones BiP, Erp57, and PDI at disease end stage p120.
Formal Description
Interaction-ID: 894

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

HSPA5

at disease end stage p120
Drugbank entries Show/Hide entries for HSPA5
Comment SOD1(G93A) mice induced the activation of caspase-12 at postnatal day 90 (p90) and disease end stage p120.
Formal Description
Interaction-ID: 895

gene/protein mutant

SOD1-p.G93A

increases_activity of

gene/protein

CASP12

at stage p90 and disease end stage p120
Comment SOD1(G93A) mice induced a significant activation of caspase-9 and caspase-3 at disease end stage p120.
Formal Description
Interaction-ID: 896

gene/protein mutant

SOD1-p.G93A

increases_activity of

gene/protein

CASP9

at disease end stage p120
Comment SOD1(G93A) mice induced a significant activation of caspase-9 and caspase-3 at disease end stage p120.
Formal Description
Interaction-ID: 897

gene/protein mutant

SOD1-p.G93A

increases_activity of

gene/protein

CASP3

at disease end stage p120
Drugbank entries Show/Hide entries for CASP3