General Information:

Id: 2,186 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
BTO:0000443 adipocyte
article
Reference: Talior I et al.(2003) Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice. Am. J. Physiol. Endocrinol. Metab. 285: E295-E302 [PMID: 12857675]

Interaction Information:

Comment Insulin-induced glucose uptake was inhibited in HF adipocytes and GLUT4 content reduced by 20% in these adipocytes.
Formal Description
Interaction-ID: 18307

environment

high-fat diet

decreases_activity of

process

glucose import

in adipose tissue; if induced by insulin and mediated by GLUT4
Comment The adipocytes used were isolated either from C57Bl/6J mice that were raised on a high-fat diet (HF) and developed obesity and insulin resistance or from control animals. Basal glucose uptake significantly increased (8-fold) in HF adipocytes, and this was accompanied with upregulation of GLUT1 expression levels.
Formal Description
Interaction-ID: 18308

environment

high-fat diet

increases_activity of

process

glucose import

in adipose tissue; if mediated by GLUT1
Comment Increased glucose intake in HF adipocytes increases oxidative stress, which in turn promotes the activation of PKC-delta.
Formal Description
Interaction-ID: 18317

process

glucose import

increases_activity of

in adipose tissue