General Information:

Id: 2,185 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
cultured rat L6 muscle cells that overexpress GLUT4
Reference: Maddux BA et al.(2001) Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes 50: 404-410 [PMID: 11272154]

Interaction Information:

Comment Oxidative stress caused a significant decrease (approximately 50%) in reduced glutathione concentration, along with the rapid activation of the stress-sensitive p38 mitogen-activated protein kinase. Pretreatment with LA prevented both of these events, coincident with protecting insulin action.
Formal Description
Interaction-ID: 18301

decreases_quantity of

drug/chemical compound


Drugbank entries Show/Hide entries for