General Information:

Id: 2,185 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
cultured rat L6 muscle cells that overexpress GLUT4
article
Reference: Maddux BA et al.(2001) Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes 50: 404-410 [PMID: 11272154]

Interaction Information:

Comment When cells were exposed to glucose oxidase and glucose to generate H2O2 and cause oxidative stress, there was a marked decrease in insulin-stimulated glucose transport. Pretreatment with LA over the concentration range of 10-1,000 pmol/l protected the insulin effect from inhibition by H2O2. Both the R and S isomers of LA were equally effective.
Formal Description
Interaction-ID: 18299

decreases_activity of

process

glucose import

Comment When cells were exposed to glucose oxidase and glucose to generate H2O2 and cause oxidative stress, there was a marked decrease in insulin-stimulated glucose transport. Pretreatment with LA over the concentration range of 10-1,000 pmol/l protected the insulin effect from inhibition by H2O2. Both the R and S isomers of LA were equally effective.
Formal Description
Interaction-ID: 18300

drug/chemical compound

Lipoate

increases_activity of

process

glucose import

after oxidative stress