General Information:

Id: 2,180 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
Nox2-/- mouse
article
Reference: Johar S et al.(2006) Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 20: 1546-1548 [PMID: 16720735]

Interaction Information:

Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18244

gene/protein

Angiotensin II

increases_activity of

complex/PPI

NADPH oxidase complex

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18245

gene/protein

Angiotensin II

increases_activity of

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18246

gene/protein

Angiotensin II

increases_expression of

gene/protein

FN1

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18247

gene/protein

Angiotensin II

increases_expression of

gene/protein

COL1A1

via CYBB
Drugbank entries Show/Hide entries for COL1A1
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18248

gene/protein

Angiotensin II

increases_expression of

gene/protein

CCN2

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18249

gene/protein

Angiotensin II

increases_activity of

gene/protein

MMP2

via CYBB
Drugbank entries Show/Hide entries for MMP2
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18250

gene/protein

Angiotensin II

increases_activity of

complex/PPI

NF-kappaB complex

via CYBB