General Information:

Id: 2,180 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
Nox2-/- mouse
article
Reference: Johar S et al.(2006) Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 20: 1546-1548 [PMID: 16720735]

Interaction Information:

Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18246

gene/protein

Angiotensin II

increases_expression of

gene/protein

FN1

via CYBB