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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	2,180 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Gender:	male
Organism Model:	Nox2-/- mouse
Publication type:	article
Reference:	Johar S et al.(2006) Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 20: 1546-1548 [PMID: 16720735]

Interaction Information:

Comment	In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description Interaction-ID: 18245	gene/protein Angiotensin II increases_activity of phenotype cardiac interstitial fibrosis via CYBB

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