General Information:

Id: 2,180
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
Nox2-/- mouse
article
Reference: Johar S et al.(2006) Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 20: 1546-1548 [PMID: 16720735]

Interaction Information:

Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18244

gene/protein

Angiotensin II

increases_activity of

complex/PPI

NADPH oxidase complex

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18245

gene/protein

Angiotensin II

increases_activity of

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18246

gene/protein

Angiotensin II

increases_expression of

gene/protein

FN1

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18247

gene/protein

Angiotensin II

increases_expression of

gene/protein

COL1A1

via CYBB
Drugbank entries Show/Hide entries for COL1A1
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18248

gene/protein

Angiotensin II

increases_expression of

gene/protein

CCN2

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18249

gene/protein

Angiotensin II

increases_activity of

gene/protein

MMP2

via CYBB
Drugbank entries Show/Hide entries for MMP2
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18250

gene/protein

Angiotensin II

increases_activity of

complex/PPI

NF-kappaB complex

via CYBB
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18252

gene/protein

CYBB

affects_activity of

complex/PPI

NADPH oxidase complex

Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18253

gene/protein

CYBB

affects_activity of

Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18254

gene/protein

CYBB

affects_expression of

gene/protein

FN1

Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18255

gene/protein

CYBB

affects_expression of

gene/protein

COL1A1

Drugbank entries Show/Hide entries for COL1A1
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18256

gene/protein

CYBB

affects_expression of

gene/protein

CCN2

Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18257

gene/protein

CYBB

affects_activity of

gene/protein

MMP2

Drugbank entries Show/Hide entries for MMP2
Comment In WT mice, subcutaneous (s.c.) AngII significantly increased NADPH oxidase activity, interstitial fibrosis, expression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, and NF-kappaB activation. These effects were all inhibited in Nox2-/- hearts.
Formal Description
Interaction-ID: 18258

gene/protein

CYBB

affects_activity of

complex/PPI

NF-kappaB complex

Comment The mineralocorticoid receptor antagonist spironolactone inhibited AngII-induced increases in NADPH oxidase activity and the increase in interstitial fibrosis.
Formal Description
Interaction-ID: 18260

drug/chemical compound

Spironolactone

decreases_activity of

complex/PPI

NADPH oxidase complex

if induced by AngII
Drugbank entries Show/Hide entries for Spironolactone
Comment The mineralocorticoid receptor antagonist spironolactone inhibited AngII-induced increases in NADPH oxidase activity and the increase in interstitial fibrosis.
Formal Description
Interaction-ID: 18261

drug/chemical compound

Spironolactone

decreases_activity of

if induced by AngII
Drugbank entries Show/Hide entries for Spironolactone
Comment In a model of mineralocorticoid-dependent hypertension involving chronic aldosterone infusion and a 1% Na Cl diet (ALDO), WT animals exhibited increased NADPH oxidase activity, pro-fibrotic COL1alpha1 and fibronectin gene expression, MMP-2 activity, NF-kappaB activation, and significant interstitial cardiac fibrosis. These effects were inhibited in Nox2-/- ALDO mice.
Formal Description
Interaction-ID: 18262

drug/chemical compound

Aldosterone

increases_activity of

complex/PPI

NADPH oxidase complex

via CYBB
Drugbank entries Show/Hide entries for Aldosterone
Comment In a model of mineralocorticoid-dependent hypertension involving chronic aldosterone infusion and a 1% Na Cl diet (ALDO), WT animals exhibited increased NADPH oxidase activity, pro-fibrotic COL1alpha1 and fibronectin gene expression, MMP-2 activity, NF-kappaB activation, and significant interstitial cardiac fibrosis. These effects were inhibited in Nox2-/- ALDO mice.
Formal Description
Interaction-ID: 18263

drug/chemical compound

Aldosterone

increases_expression of

gene/protein

COL1A1

via CYBB
Drugbank entries Show/Hide entries for Aldosterone or COL1A1
Comment In a model of mineralocorticoid-dependent hypertension involving chronic aldosterone infusion and a 1% Na Cl diet (ALDO), WT animals exhibited increased NADPH oxidase activity, pro-fibrotic COL1alpha1 and fibronectin gene expression, MMP-2 activity, NF-kappaB activation, and significant interstitial cardiac fibrosis. These effects were inhibited in Nox2-/- ALDO mice.
Formal Description
Interaction-ID: 18264

drug/chemical compound

Aldosterone

increases_expression of

gene/protein

FN1

via CYBB
Drugbank entries Show/Hide entries for Aldosterone
Comment In a model of mineralocorticoid-dependent hypertension involving chronic aldosterone infusion and a 1% Na Cl diet (ALDO), WT animals exhibited increased NADPH oxidase activity, pro-fibrotic COL1alpha1 and fibronectin gene expression, MMP-2 activity, NF-kappaB activation, and significant interstitial cardiac fibrosis. These effects were inhibited in Nox2-/- ALDO mice.
Formal Description
Interaction-ID: 18265

drug/chemical compound

Aldosterone

increases_activity of

gene/protein

MMP2

via CYBB
Drugbank entries Show/Hide entries for Aldosterone or MMP2
Comment In a model of mineralocorticoid-dependent hypertension involving chronic aldosterone infusion and a 1% Na Cl diet (ALDO), WT animals exhibited increased NADPH oxidase activity, pro-fibrotic COL1alpha1 and fibronectin gene expression, MMP-2 activity, NF-kappaB activation, and significant interstitial cardiac fibrosis. These effects were inhibited in Nox2-/- ALDO mice.
Formal Description
Interaction-ID: 18266

drug/chemical compound

Aldosterone

increases_activity of

complex/PPI

NF-kappaB complex

via CYBB
Drugbank entries Show/Hide entries for Aldosterone
Comment In a model of mineralocorticoid-dependent hypertension involving chronic aldosterone infusion and a 1% Na Cl diet (ALDO), WT animals exhibited increased NADPH oxidase activity, pro-fibrotic COL1alpha1 and fibronectin gene expression, MMP-2 activity, NF-kappaB activation, and significant interstitial cardiac fibrosis. These effects were inhibited in Nox2-/- ALDO mice.
Formal Description
Interaction-ID: 18267

drug/chemical compound

Aldosterone

increases_activity of

via CYBB
Drugbank entries Show/Hide entries for Aldosterone
Comment Aldosterone-dependent activation of a Nox2-containing NADPH oxidase contributes to the profibrotic effect of AngII in the heart as well as the fibrosis seen in mineralocorticoid-dependent hypertension.
Formal Description
Interaction-ID: 18268

gene/protein

CYBB

is_part_of

complex/PPI

NADPH oxidase complex