General Information:

Id: 215 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0000143 substantia nigra; SN4741 cell
article
Reference: Yang Q et al.(2009) Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323: 124-127 [PMID: 19119233]

Interaction Information:

Comment Blocking lysosomal proteolysis (autophagy) with ammonia chloride in a mouse midbrain dopaminergic cell line, SN4741, cause a dose-dependent increase in the level of MEF2D.
Formal Description
Interaction-ID: 850

process

autophagy

decreases_quantity of

gene/protein

MEF2D

Comment Both wild-type alpha-synuclein and disease-causing mutant SNCA-A53T inhibit CMA-mediated degradation of MEF2D.
Formal Description
Interaction-ID: 13596

gene/protein mutant

SNCA-p.A53T

decreases_activity of

process

autophagy

thus increasing the amount of MEF2D