General Information:

Id: 215
Diseases: Parkinson disease
Mus musculus
BTO:0000143 substantia nigra; SN4741 cell
article
Reference: Yang Q et al.(2009) Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323: 124-127 [PMID: 19119233]

Interaction Information:

Comment Blocking lysosomal proteolysis (autophagy) with ammonia chloride in a mouse midbrain dopaminergic cell line, SN4741, cause a dose-dependent increase in the level of MEF2D.
Formal Description
Interaction-ID: 850

process

autophagy

decreases_quantity of

gene/protein

MEF2D

Comment MEF2D is localized in the neuronal nucleus, and is constantly exported from the nucleus to the cytoplasm for lysosomal degradation.
Formal Description
Interaction-ID: 853

gene/protein

MEF2D

is localized in

cellular component

nucleus

Comment MEF2D is localized in the neuronal nucleus, and is constantly exported from the nucleus to the cytoplasm for lysosomal degradation.
Formal Description
Interaction-ID: 856

gene/protein

MEF2D

is localized in

cellular component

cytoplasm

Comment Hsc70 interacts with MEF2D.
Formal Description
Interaction-ID: 859

gene/protein

HSPA8

interacts (colocalizes) with

gene/protein

MEF2D

Drugbank entries Show/Hide entries for HSPA8
Comment Both wild-type alpha-synuclein and disease-causing mutant SNCA-A53T inhibit CMA-mediated degradation of MEF2D.
Formal Description
Interaction-ID: 910

gene/protein

SNCA

increases_quantity of

gene/protein

MEF2D

by inhibiting CMA-mediated degradation of MEF2D
Comment Overexpression of wild-type (alpha)-synuclein or SNCA-A53T mutant reduced the interaction of endogenous MEF2D and Hsc70.
Formal Description
Interaction-ID: 912

gene/protein

SNCA

decreases_quantity of

complex/PPI

MEF2D-HSC70 complex

if SNCA is overexpressed
Comment Overexpression of wild-type (alpha)-synuclein or SNCA-A53T mutant reduced the interaction of endogenous MEF2D and Hsc70.
Formal Description
Interaction-ID: 913

gene/protein mutant

SNCA-p.A53T

decreases_quantity of

complex/PPI

MEF2D-HSC70 complex

if SNCA-p.A53T is overexpressed
Comment Increasing the level of wild-type or A53T alpha-synuclein inhibited the uptake of MEF2D by lysosomes.
Formal Description
Interaction-ID: 914

gene/protein

SNCA

decreases transport of

gene/protein

MEF2D

into lysosomes; if SNCA is overexpressed
Comment Increasing the level of wild-type or A53T alpha-synuclein inhibited the uptake of MEF2D by lysosomes.
Formal Description
Interaction-ID: 915

gene/protein mutant

SNCA-p.A53T

decreases transport of

gene/protein

MEF2D

into lysosomes; if SNCA-p.A53T is overexpressed
Comment Both wild-type alpha-synuclein and disease-causing mutant SNCA-A53T inhibit CMA-mediated degradation of MEF2D.
Formal Description
Interaction-ID: 1309

gene/protein mutant

SNCA-p.A53T

increases_quantity of

gene/protein

MEF2D

by inhibiting CMA-mediated degradation of MEF2D
Comment Level of MEF2 protein is critical to neuronal survival.
Formal Description
Interaction-ID: 2860

gene/protein

MEF2D

affects_activity of

process

neuron death

Comment Both wild-type alpha-synuclein and disease-causing mutant SNCA-A53T inhibit CMA-mediated degradation of MEF2D.
Formal Description
Interaction-ID: 13596

gene/protein mutant

SNCA-p.A53T

decreases_activity of

process

autophagy

thus increasing the amount of MEF2D