General Information:

Id: 2,143 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
APP/PS1 mouse model
article
Reference: Liu RM et al.(2011) Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimers disease. Neurobiol. Aging 32: 1079-1089 [PMID: 19604604]

Interaction Information:

Comment Expression of plasminogen activator inhibitor 1 (Serpine1 / PAI-1), a physiological inhibitor of tissue type and urokinase type plasminogen activators (tPA and uPA), increases with age in the brain of wild type and Abeta precursor protein-presenilin 1 (APP/PS1) transgenic mice as well as in AD patients.
Formal Description
Interaction-ID: 17843

process

aging

increases_expression of

gene/protein

SERPINE1

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