CIDeRGeneral Information:
| Id: | 2,138 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| article | |
| Reference: | Nofer JR et al.(2004) HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J. Clin. Invest. 113: 569-581 [PMID: 14966566] |
Interaction Information:
| Comment | The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation. |
|
Formal Description Interaction-ID: 17657 |
drug/chemical compound Sphingosylphosphorylcholine increases_quantity of drug/chemical compound |