General Information:

Id: 2,138 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Nofer JR et al.(2004) HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J. Clin. Invest. 113: 569-581 [PMID: 14966566]

Interaction Information:

Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17657

drug/chemical compound


increases_quantity of

drug/chemical compound