General Information:

Id: 2,138
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Nofer JR et al.(2004) HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J. Clin. Invest. 113: 569-581 [PMID: 14966566]

Interaction Information:

Comment HDL-induced vasodilation is dependent on eNOS in vitro and in aortic segments.
Formal Description
Interaction-ID: 17647

complex/PPI

HDL

increases_activity of

process

vasodilation

Comment HDL-induced vasodilation is dependent on eNOS in vitro and in aortic segments.
Formal Description
Interaction-ID: 17648

gene/protein

NOS3

affects_activity of

process

vasodilation

if induced by HDL
Drugbank entries Show/Hide entries for NOS3
Comment HDL induces vasodilation via Akt-stimulated eNOS phosphorylation of Ser1177 in endothelial cells and in aortic segments.
Formal Description
Interaction-ID: 17649

complex/PPI

HDL

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment HDL induces vasodilation via Akt-stimulated eNOS phosphorylation of Ser1177 in endothelial cells and in aortic segments.
Formal Description
Interaction-ID: 17650

gene/protein

AKT1

increases_phosphorylation of

gene/protein

NOS3

at Ser1177, if induced by HDL
Drugbank entries Show/Hide entries for AKT1 or NOS3
Comment HDL and the HDL-associated lysophospholipids SPC (sphingosylphosphorylcholine), S1P (sphingosine-1-phosphate), and LSF (lysosulfatide) induce vasorelaxation in aortic segments in vitro and in adult rats in vivo.
Formal Description
Interaction-ID: 17651

drug/chemical compound

Sphingosylphosphorylcholine

is_part_of

complex/PPI

HDL

Comment HDL and the HDL-associated lysophospholipids SPC (sphingosylphosphorylcholine), S1P (sphingosine-1-phosphate), and LSF (lysosulfatide) induce vasorelaxation in aortic segments in vitro and in adult rats in vivo.
Formal Description
Interaction-ID: 17652

drug/chemical compound

Sphingosine 1-phosphate

is_part_of

complex/PPI

HDL

Comment HDL and the HDL-associated lysophospholipids SPC (sphingosylphosphorylcholine), S1P (sphingosine-1-phosphate), and LSF (lysosulfatide) induce vasorelaxation in aortic segments in vitro and in adult rats in vivo.
Formal Description
Interaction-ID: 17653

drug/chemical compound

Lysosulfatide

is_part_of

complex/PPI

HDL

Comment HDL and the HDL-associated lysophospholipids SPC (sphingosylphosphorylcholine), S1P (sphingosine-1-phosphate), and LSF (lysosulfatide) induce vasorelaxation in aortic segments in vitro and in adult rats in vivo.
Formal Description
Interaction-ID: 17654

drug/chemical compound

Sphingosylphosphorylcholine

increases_activity of

process

vasodilation

Comment HDL and the HDL-associated lysophospholipids SPC (sphingosylphosphorylcholine), S1P (sphingosine-1-phosphate), and LSF (lysosulfatide) induce vasorelaxation in aortic segments in vitro and in adult rats in vivo.
Formal Description
Interaction-ID: 17655

drug/chemical compound

Sphingosine 1-phosphate

increases_activity of

process

vasodilation

Comment HDL and the HDL-associated lysophospholipids SPC (sphingosylphosphorylcholine), S1P (sphingosine-1-phosphate), and LSF (lysosulfatide) induce vasorelaxation in aortic segments in vitro and in adult rats in vivo.
Formal Description
Interaction-ID: 17656

drug/chemical compound

Lysosulfatide

increases_activity of

process

vasodilation

Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17657

drug/chemical compound

Sphingosylphosphorylcholine

increases_quantity of

drug/chemical compound

Ca2+

Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17659

drug/chemical compound

Sphingosine 1-phosphate

increases_quantity of

drug/chemical compound

Ca2+

Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17660

drug/chemical compound

Lysosulfatide

increases_quantity of

drug/chemical compound

Ca2+

Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17662

drug/chemical compound

Sphingosylphosphorylcholine

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17663

drug/chemical compound

Sphingosine 1-phosphate

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17664

drug/chemical compound

Lysosulfatide

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17667

drug/chemical compound

Sphingosylphosphorylcholine

increases_activity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3
Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17668

drug/chemical compound

Sphingosine 1-phosphate

increases_activity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3
Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17669

drug/chemical compound

Lysosulfatide

increases_activity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3
Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17670

drug/chemical compound

Sphingosylphosphorylcholine

increases_quantity of

drug/chemical compound

NO

Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17671

drug/chemical compound

Sphingosine 1-phosphate

increases_quantity of

drug/chemical compound

NO

Comment The three lysophospholipids present in HDL: sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF) elevated intracellular Ca2+ concentration and activated Akt and eNOS, which resulted in NO release and vasodilation.
Formal Description
Interaction-ID: 17672

drug/chemical compound

Lysosulfatide

increases_quantity of

drug/chemical compound

NO

Comment Deficiency of the lysophospholipid receptor S1P3 (also known as LPB3 and EDG3) abolished the vasodilatory effects of SPC, S1P, and LSF and reduced the effect of HDL by approximately 60%.
Formal Description
Interaction-ID: 17673

gene/protein

S1PR3

affects_activity of

process

vasodilation

if induced by HDL, SPC, S1P, or LSF
Comment In endothelial cells from S1P3-deficient mice, Akt phosphorylation and Ca2+ increase in response to HDL and lysophospholipids were severely reduced.
Formal Description
Interaction-ID: 17675

gene/protein

S1PR3

affects_activity of

gene/protein

AKT1

if induced by HDL, SPC, S1P, or LSF
Drugbank entries Show/Hide entries for AKT1
Comment In endothelial cells from S1P3-deficient mice, Akt phosphorylation and Ca2+ increase in response to HDL and lysophospholipids were severely reduced.
Formal Description
Interaction-ID: 17676

gene/protein

S1PR3

affects_quantity of

drug/chemical compound

Ca2+

if induced by HDL, SPC, S1P, or LSF
Comment In vivo, intra-arterial administration of HDL or lysophospholipids lowered mean arterial blood pressure in rats.
Formal Description
Interaction-ID: 17677

complex/PPI

HDL

increases_activity of

Comment In vivo, intra-arterial administration of HDL or lysophospholipids lowered mean arterial blood pressure in rats.
Formal Description
Interaction-ID: 17679

drug/chemical compound

Sphingosylphosphorylcholine

increases_activity of

Comment In vivo, intra-arterial administration of HDL or lysophospholipids lowered mean arterial blood pressure in rats.
Formal Description
Interaction-ID: 17680

drug/chemical compound

Sphingosine 1-phosphate

increases_activity of

Comment In vivo, intra-arterial administration of HDL or lysophospholipids lowered mean arterial blood pressure in rats.
Formal Description
Interaction-ID: 17681

drug/chemical compound

Lysosulfatide

increases_activity of

Comment HDL induces vasodilation via Akt-stimulated eNOS phosphorylation of Ser1177 in endothelial cells and in aortic segments.
Formal Description
Interaction-ID: 17683

gene/protein

AKT1

increases_activity of

gene/protein

NOS3

via phosphorylation at Ser1177
Drugbank entries Show/Hide entries for AKT1 or NOS3