General Information:

Id: 2,119 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Oelze M et al.(2006) Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 48: 677-684 [PMID: 16940222]

Interaction Information:

Comment Vascular NADPH oxidase activity, as well as expression at the mRNA and protein level, were markedly upregulated in Ang II-treated animals, superoxide production (NADPH oxidase activity) in heart membranes of Ang II-treated animals was concentration-dependently inhibited by nebivolol. With respect to other beta-blockers, carvedilol but not atenolol and metoprolol were able to inhibit superoxide production to a similar extent.
Formal Description
Interaction-ID: 17375

gene/protein

Angiotensin II

increases_activity of

complex/PPI

NADPH oxidase complex