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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	2,119 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Rattus norvegicus
Gender:	male
Publication type:	article
Reference:	Oelze M et al.(2006) Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 48: 677-684 [PMID: 16940222]

Interaction Information:

Comment	Vascular NADPH oxidase activity, as well as expression at the mRNA and protein level, were markedly upregulated in Ang II-treated animals, superoxide production (NADPH oxidase activity) in heart membranes of Ang II-treated animals was concentration-dependently inhibited by nebivolol. With respect to other beta-blockers, carvedilol but not atenolol and metoprolol were able to inhibit superoxide production to a similar extent.
Formal Description Interaction-ID: 17375	gene/protein Angiotensin II increases_activity of complex/PPI NADPH oxidase complex

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