General Information:

Id: 2,108
Diseases: Autism - [OMIM]
Homo sapiens
BTO:0000131 blood plasma
article
Reference: Croonenberghs J et al.(2000) Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder Neuropsychopharmacology 22: 275-283 [PMID: 10693155]

Interaction Information:

Comment Plasma concentrations of tryptophan, the precursor of 5-HT, were significantly lower in autistic patients than in healthy volunteers.
Formal Description
Interaction-ID: 17221

disease

Autism

decreases_quantity of

drug/chemical compound

Tryptophan

Comment There were no significant differences between autistic and normal children in the serum concentrations of 5-HT.
Formal Description
Interaction-ID: 17224

disease

Autism

NOT affects_quantity of

drug/chemical compound

5-Hydroxytryptophan

Comment There were no significant differences in the serum concentrations of tyrosine between both study groups.
Formal Description
Interaction-ID: 17225

disease

Autism

NOT affects_quantity of

drug/chemical compound

Tyrosine

Comment There were highly significant positive correlations between age (from 12 until 18 years)and level of serum tryptophan.
Formal Description
Interaction-ID: 17226

process

aging

increases_quantity of

drug/chemical compound

Tryptophan

Comment The serotonergic disturbances, such as defects in the 5-HT transporter system and lowered plasma tryptophan, may play a role in the pathophysiology of autism.
Formal Description
Interaction-ID: 17232

affects_activity of

disease

Autism

Comment [3H]-paroxetine binding Kd values were significantly higher in patients with autism than in healthy volunteers.
Formal Description
Interaction-ID: 17233

disease

Autism

affects_activity of

drug/chemical compound

Paroxetine

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