General Information:

Id: 2,088 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Schmidt AM et al.(1999) Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ. Res. 84: 489-497 [PMID: 10082470]

Interaction Information:

Comment In the endothelium, AGEs diminish vascular barrier function, enhance expression of vascular cell adhesion molecule-1 (VCAM-1), quench nitric oxide, and alter the balance of cellular coagulant properties, in part through induction of procoagulant tissue factor.
Formal Description
Interaction-ID: 16841

drug/chemical compound

Advanced glycation end-product

affects_activity of

process

coagulation