General Information:

Id: 2,083 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Bos taurus
BTO:0003247 BAEC cell
Reference: Nishikawa T et al.(2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404: 787-790 [PMID: 10783895]

Interaction Information:

Comment Excessive production of advanced glycation end-products (AGEs) also appears to be important in the pathogenesis of diabetic complications. Normalizing levels of mitochondrial reactive oxygen species prevents formation of advanced glycation end-products.
Formal Description
Interaction-ID: 16817

drug/chemical compound

Reactive oxygen species

increases_quantity of

drug/chemical compound

Advanced glycation end-product