General Information:

Id: 2,072 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
ApoE4 mouse
article
Reference: Shenk JC et al.(2009) The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimers disease J. Neurol. Sci. 283: 199-206 [PMID: 19342064]

Interaction Information:

Comment Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description
Interaction-ID: 95894

drug/chemical compound

mitochondrial antioxidants

decreases_activity of

gene/protein mutant

APOE (isoform E4)

in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid