General Information:

Id: 2,071 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Mus musculus
male
diabetic db/db mouse
article
Reference: Shibuya K et al.(2005) N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice. Diabetes 54: 838-845 [PMID: 15734863]

Interaction Information:

Comment The nuclear translocation of Smad3 in glomeruli of the outer cortex was increased in db/db mice, the nuclear translocation of Smad3 was inhibited by Ac-SDKP. Ac-SDKP inhibited TGF-beta/Smad signaling in vivo.
Formal Description
Interaction-ID: 16708

gene/protein

AcSDKP

decreases_activity of

process

transforming growth factor beta receptor signaling pathway

in db/db mice