General Information:

Id: 205 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0000601 hippocampus; BTO:0002705 septal area; BTO:0000043 cerebellar cortex
article
Reference: Cheng B et al.(1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis Neuron 12: 139-153 [PMID: 7507336]

Interaction Information:

Comment Glucose depriviation-induced neuronal injury was significantly reduced in hippocampal, septal, and cortical cultures pretreated with TNFalpha (TNF) or TNFbeta (LTA).
Formal Description
Interaction-ID: 817

gene/protein

TNF

decreases_activity of

Drugbank entries Show/Hide entries for TNF
Comment TNFalpha (TNF) and TNFbeta (LTA) promote maintenance of cellular calcium homeostasis. Ischemic/excitotoxic injury results in large part from aberrant elevations of calcium ions.
Formal Description
Interaction-ID: 826

gene/protein

TNF

decreases_activity of

Drugbank entries Show/Hide entries for TNF
Comment TNFalpha (TNF) and TNFbeta (LTA) increase the number of neurons expressing the calcium-binding protein calbindin 1 (CALB1) 4-8 fold.
Formal Description
Interaction-ID: 828

gene/protein

TNF

increases_expression of

gene/protein

CALB1

Drugbank entries Show/Hide entries for TNF
Comment TNFalpha (TNF) and TNFbeta (LTA) increase the number of neurons expressing the calcium-binding protein calbindin 1 (CALB1) 4-8 fold.
Formal Description
Interaction-ID: 13713

gene/protein

TNF

increases_activity of

process

neurogenesis

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