Welcome to cider

Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	2,039 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Publication type:	article
Reference:	Mitsuishi M et al.(2009) Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control. Diabetes 58: 710-717 [PMID: 19074984]

Interaction Information:

Comment	AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description Interaction-ID: 16265	gene/protein Angiotensin II decreases_quantity of cellular component mitochondrion

Comment	AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description Interaction-ID: 16266	gene/protein Angiotensin II increases_quantity of drug/chemical compound Reactive oxygen species in mitochondria

Comment	AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description Interaction-ID: 16267	gene/protein Angiotensin II affects_activity of process regulation of mitochondrial membrane potential

Comment	Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description Interaction-ID: 16279	gene/protein Angiotensin II increases_activity of phenotype impaired glucose tolerance

Comment	Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description Interaction-ID: 16280	gene/protein Angiotensin II NOT affects_activity of phenotype abnormal body weight

Comment	Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description Interaction-ID: 16281	gene/protein Angiotensin II NOT affects_activity of phenotype abnormal food intake

Comment	AngII reduces mitochondrial content and increases triglycerides in the skeletal muscle in both AT1R- and AT2R-dependent manners.
Formal Description Interaction-ID: 16282	gene/protein Angiotensin II increases_quantity of drug/chemical compound Triacylglycerol in skeletal muscle

Comment	Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description Interaction-ID: 16285	gene/protein Angiotensin II decreases_expression of gene/protein PPARGC1A via AGTR2

Comment	Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description Interaction-ID: 16286	gene/protein Angiotensin II decreases_expression of gene/protein TFAM via AGTR2

Comment	The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description Interaction-ID: 16293	gene/protein Angiotensin II decreases_quantity of complex/PPI Mitochondrial respiratory chain complex V in mitochondria; via AGTR1 or AGTR2

Comment	The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description Interaction-ID: 16294	gene/protein Angiotensin II decreases_quantity of complex/PPI Mitochondrial respiratory chain complex IV in mitochondria; via AGTR1 or AGTR2

Comment	The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description Interaction-ID: 16295	gene/protein Angiotensin II decreases_expression of gene/protein ACADM in mitochondria; via AGTR1 or AGTR2
Drugbank entries	Show/Hide entries for ACADM
Drugbank DB02910	Octanoyl-Coenzyme A not specified ACADM
Drugbank DB03147	Flavin-Adenine Dinucleotide not specified ACADM
Drugbank DB03415	3-Thiaoctanoyl-Coenzyme A not specified ACADM
Drugbank DB02910	Octanoyl-Coenzyme A not specified ACADM
Drugbank DB03147	Flavin-Adenine Dinucleotide not specified ACADM
Drugbank DB03415	3-Thiaoctanoyl-Coenzyme A not specified ACADM

Home
Contact

The Helmholtz Zentrum München Imprint and Privacy Policy apply.

© 2013 - Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH) Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany

Disclaimer: IBIS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The Helmholtz Zentrum München has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of IBIS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted. Commercial users shall contact the Helmholtz Zentrum München for a separate users license.