General Information:

Id: 2,039 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Mitsuishi M et al.(2009) Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control. Diabetes 58: 710-717 [PMID: 19074984]

Interaction Information:

Comment AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description
Interaction-ID: 16265

gene/protein

Angiotensin II

decreases_quantity of

cellular component

mitochondrion

Comment AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description
Interaction-ID: 16266

gene/protein

Angiotensin II

increases_quantity of

drug/chemical compound

Reactive oxygen species

in mitochondria
Comment AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description
Interaction-ID: 16267

gene/protein

Angiotensin II

affects_activity of

Comment Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description
Interaction-ID: 16279

gene/protein

Angiotensin II

increases_activity of

Comment Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description
Interaction-ID: 16280

gene/protein

Angiotensin II

NOT affects_activity of

Comment Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description
Interaction-ID: 16281

gene/protein

Angiotensin II

NOT affects_activity of

Comment AngII reduces mitochondrial content and increases triglycerides in the skeletal muscle in both AT1R- and AT2R-dependent manners.
Formal Description
Interaction-ID: 16282

gene/protein

Angiotensin II

increases_quantity of

drug/chemical compound

Triacylglycerol

in skeletal muscle
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16285

gene/protein

Angiotensin II

decreases_expression of

gene/protein

PPARGC1A

via AGTR2
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16286

gene/protein

Angiotensin II

decreases_expression of

gene/protein

TFAM

via AGTR2
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16293

gene/protein

Angiotensin II

decreases_quantity of

complex/PPI

Mitochondrial respiratory chain complex V

in mitochondria; via AGTR1 or AGTR2
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16294

gene/protein

Angiotensin II

decreases_quantity of

complex/PPI

Mitochondrial respiratory chain complex IV

in mitochondria; via AGTR1 or AGTR2
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16295

gene/protein

Angiotensin II

decreases_expression of

gene/protein

ACADM

in mitochondria; via AGTR1 or AGTR2
Drugbank entries Show/Hide entries for ACADM