General Information:

Id: 2,039
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Mitsuishi M et al.(2009) Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control. Diabetes 58: 710-717 [PMID: 19074984]

Interaction Information:

Comment AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description
Interaction-ID: 16265

gene/protein

Angiotensin II

decreases_quantity of

cellular component

mitochondrion

Comment AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description
Interaction-ID: 16266

gene/protein

Angiotensin II

increases_quantity of

drug/chemical compound

Reactive oxygen species

in mitochondria
Comment AngII reduces mitochondrial content in association with increased mitochondrial ROS production and lowers mitochondrial membrane potential in C2C12 cells.
Formal Description
Interaction-ID: 16267

gene/protein

Angiotensin II

affects_activity of

Comment Blockade of AT2R but not AT1R reverses mitochondrial reduction in C2C12 cells caused by AngII, whereas blockade of either AT1R or AT2R suppresses AngII-induced changes in mtROS and mtMP.
Formal Description
Interaction-ID: 16268

gene/protein

AGTR2

affects_quantity of

cellular component

mitochondrion

Drugbank entries Show/Hide entries for AGTR2
Comment Blockade of AT2R but not AT1R reverses mitochondrial reduction in C2C12 cells caused by AngII, whereas blockade of either AT1R or AT2R suppresses AngII-induced changes in mtROS and mtMP.
Formal Description
Interaction-ID: 16269

gene/protein

AGTR1

NOT affects_quantity of

cellular component

mitochondrion

Drugbank entries Show/Hide entries for AGTR1
Comment Blockade of AT2R but not AT1R reverses mitochondrial reduction in C2C12 cells caused by AngII, whereas blockade of either AT1R or AT2R suppresses AngII-induced changes in mtROS and mtMP.
Formal Description
Interaction-ID: 16270

gene/protein

AGTR2

affects_quantity of

drug/chemical compound

Reactive oxygen species

in mitochondria
Drugbank entries Show/Hide entries for AGTR2
Comment Blockade of AT2R but not AT1R reverses mitochondrial reduction in C2C12 cells caused by AngII, whereas blockade of either AT1R or AT2R suppresses AngII-induced changes in mtROS and mtMP.
Formal Description
Interaction-ID: 16271

gene/protein

AGTR1

affects_quantity of

drug/chemical compound

Reactive oxygen species

in mitochondria
Drugbank entries Show/Hide entries for AGTR1
Comment Blockade of AT2R but not AT1R reverses mitochondrial reduction in C2C12 cells caused by AngII, whereas blockade of either AT1R or AT2R suppresses AngII-induced changes in mtROS and mtMP.
Formal Description
Interaction-ID: 16272

gene/protein

AGTR2

affects_activity of

Drugbank entries Show/Hide entries for AGTR2
Comment Blockade of AT2R but not AT1R reverses mitochondrial reduction in C2C12 cells caused by AngII, whereas blockade of either AT1R or AT2R suppresses AngII-induced changes in mtROS and mtMP.
Formal Description
Interaction-ID: 16273

gene/protein

AGTR1

affects_activity of

Drugbank entries Show/Hide entries for AGTR1
Comment Overexpression of AT2R in C2C12 cells augments AngII-induced reduction in mitochondrial biogenesis.
Formal Description
Interaction-ID: 16274

gene/protein

AGTR2

affects_activity of

Drugbank entries Show/Hide entries for AGTR2
Comment Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description
Interaction-ID: 16279

gene/protein

Angiotensin II

increases_activity of

Comment Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description
Interaction-ID: 16280

gene/protein

Angiotensin II

NOT affects_activity of

Comment Exogenous administration of AngII in mice for 1 week provokes glucose intolerance without changes in body weight or food intake.
Formal Description
Interaction-ID: 16281

gene/protein

Angiotensin II

NOT affects_activity of

Comment AngII reduces mitochondrial content and increases triglycerides in the skeletal muscle in both AT1R- and AT2R-dependent manners.
Formal Description
Interaction-ID: 16282

gene/protein

Angiotensin II

increases_quantity of

drug/chemical compound

Triacylglycerol

in skeletal muscle
Comment AngII reduces mitochondrial content and increases triglycerides in the skeletal muscle in both AT1R- and AT2R-dependent manners.
Formal Description
Interaction-ID: 16283

gene/protein

AGTR1

affects_quantity of

drug/chemical compound

Triacylglycerol

in skeletal muscle
Drugbank entries Show/Hide entries for AGTR1
Comment AngII reduces mitochondrial content and increases triglycerides in the skeletal muscle in both AT1R- and AT2R-dependent manners.
Formal Description
Interaction-ID: 16284

gene/protein

AGTR2

affects_quantity of

drug/chemical compound

Triacylglycerol

in skeletal muscle
Drugbank entries Show/Hide entries for AGTR2
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16285

gene/protein

Angiotensin II

decreases_expression of

gene/protein

PPARGC1A

via AGTR2
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16286

gene/protein

Angiotensin II

decreases_expression of

gene/protein

TFAM

via AGTR2
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16287

gene/protein

AGTR2

affects_expression of

gene/protein

PPARGC1A

Drugbank entries Show/Hide entries for AGTR2
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16288

gene/protein

AGTR1

NOT affects_expression of

gene/protein

PPARGC1A

Drugbank entries Show/Hide entries for AGTR1
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16289

gene/protein

AGTR2

affects_expression of

gene/protein

TFAM

Drugbank entries Show/Hide entries for AGTR2
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16290

gene/protein

AGTR1

NOT affects_expression of

gene/protein

TFAM

Drugbank entries Show/Hide entries for AGTR1
Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16291

gene/protein

TFAM

affects_activity of

Comment Blockade of AT2R but not AT1R in AngII-infused mice reverses reduction in expression and protein levels of molecules involved in mitochondrial biogenesis, such as PGC1-alpha and Tfam.
Formal Description
Interaction-ID: 16292

gene/protein

PPARGC1A

affects_activity of

Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16293

gene/protein

Angiotensin II

decreases_quantity of

complex/PPI

Mitochondrial respiratory chain complex V

in mitochondria; via AGTR1 or AGTR2
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16294

gene/protein

Angiotensin II

decreases_quantity of

complex/PPI

Mitochondrial respiratory chain complex IV

in mitochondria; via AGTR1 or AGTR2
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16295

gene/protein

Angiotensin II

decreases_expression of

gene/protein

ACADM

in mitochondria; via AGTR1 or AGTR2
Drugbank entries Show/Hide entries for ACADM
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16296

gene/protein

AGTR1

affects_quantity of

complex/PPI

Mitochondrial respiratory chain complex V

in mitochondria
Drugbank entries Show/Hide entries for AGTR1
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16297

gene/protein

AGTR1

affects_quantity of

complex/PPI

Mitochondrial respiratory chain complex IV

in mitochondria
Drugbank entries Show/Hide entries for AGTR1
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16298

gene/protein

AGTR1

affects_expression of

gene/protein

ACADM

in mitochondria
Drugbank entries Show/Hide entries for AGTR1 or ACADM
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16300

gene/protein

AGTR2

affects_quantity of

complex/PPI

Mitochondrial respiratory chain complex V

in mitochondria
Drugbank entries Show/Hide entries for AGTR2
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16301

gene/protein

AGTR2

affects_quantity of

complex/PPI

Mitochondrial respiratory chain complex IV

in mitochondria
Drugbank entries Show/Hide entries for AGTR2
Comment The AngII-induced reduction in mitochondrial proteins involved in electron transport or fatty acid oxidation (ATP synthase, COX, and medium-chain fatty acyl-CoA dehydrogenase) were all suppressed by blockade of either AT1R or AT2R.
Formal Description
Interaction-ID: 16302

gene/protein

AGTR2

affects_expression of

gene/protein

ACADM

in mitochondria
Drugbank entries Show/Hide entries for AGTR2 or ACADM