General Information:

Id: 202 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0000938 neuron
article
Reference: Taoufik E et al.(2008) TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proc. Natl. Acad. Sci. U.S.A. 105: 6185-6190 [PMID: 18413601]

Interaction Information:

Comment Erythropoietin (EPO) and VEGF (VEGFA) protect cortical neurons in diverse models of neuronal death. Experiments with TNFR1 KO mice showed, that TNFR1 activity is required for this neuroprotective process.
Formal Description
Interaction-ID: 802

gene/protein

EPO

decreases_activity of

process

neuron death

Comment Erythropoietin (EPO) and VEGF (VEGFA) protect cortical neurons in diverse models of neuronal death. Experiments with TNFR1 KO mice showed, that TNFR1 activity is required for this neuroprotective process.
Formal Description
Interaction-ID: 803

gene/protein

VEGFA

decreases_activity of

process

neuron death

Drugbank entries Show/Hide entries for VEGFA
Comment Erythropoietin (EPO) and VEGF (VEGFA) protect cortical neurons in diverse models of neuronal death. Experiments with TNFR1 KO mice showed, that TNFR1 (TNFRSF1A) activity is required for this neuroprotective process.
Formal Description
Interaction-ID: 804

gene/protein

TNFRSF1A

decreases_activity of

process

neuron death

Drugbank entries Show/Hide entries for TNFRSF1A
Comment Kainate-induced neurotoxicity is an acute and selective model of neuronal death.
Formal Description
Interaction-ID: 809

drug/chemical compound

Kainic acid

increases_activity of

process

neuron death