General Information:

Id: 2,022 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Metabolic syndrome
Homo sapiens
article
Reference: Yilmaz MI et al.(2007) Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome. Nephrology (Carlton) 12: 147-153 [PMID: 17371337]

Interaction Information:

Comment After treatment with doxazosin, an alpha blocker, the plasma adiponectin concentrations significantly increased and serum insulin levels and HOMA indexes significantly decreased, total cholesterol levels decreased while there was no difference in the other lipid parameters.
Formal Description
Interaction-ID: 16037

drug/chemical compound

Doxazosin

decreases_quantity of

drug/chemical compound

Cholesterol

in blood
Drugbank entries Show/Hide entries for Doxazosin or Cholesterol
Comment After treatment with amlodipine, a calcium channel blocker, the plasma adiponectin concentrations significantly increased and serum insulin levels and HOMA indexes significantly decreased, total cholesterol levels decreased while there was no difference in the other lipid parameters.
Formal Description
Interaction-ID: 16050

drug/chemical compound

Amlodipine

decreases_quantity of

drug/chemical compound

Cholesterol

in blood
Drugbank entries Show/Hide entries for Amlodipine or Cholesterol
Comment After treatment with ramipril, an ACE inhibitor, or valsartan, an angiotensin II receptor blocker, plasma adiponectin concentrations increased and plasma insulin levels and HOMA indexes decreased significantly in both regimens. Triglycerides, total cholesterol levels, LDL-cholesterol levels decreased and HDL-cholesterol levels increased in both regimens.
Formal Description
Interaction-ID: 16069

drug/chemical compound

Ramipril

decreases_quantity of

drug/chemical compound

Cholesterol

in blood
Drugbank entries Show/Hide entries for Ramipril or Cholesterol
Comment After treatment with ramipril, an ACE inhibitor, or valsartan, an angiotensin II receptor blocker, plasma adiponectin concentrations increased and plasma insulin levels and HOMA indexes decreased significantly in both regimens. Triglycerides, total cholesterol levels, LDL-cholesterol levels decreased and HDL-cholesterol levels increased in both regimens.
Formal Description
Interaction-ID: 16070

drug/chemical compound

Valsartan

decreases_quantity of

drug/chemical compound

Cholesterol

in blood
Drugbank entries Show/Hide entries for Valsartan or Cholesterol