General Information:

Id: 2,019
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
BTO:0001456 white adipose tissue
article
Reference: Saint-Marc P et al.(2001) Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formation. Endocrinology 142: 487-492 [PMID: 11145613]

Interaction Information:

Comment Based upon in vivo and ex vivo experiments combined to immunocytochemical staining of glycerol-3-phosphate dehydrogenase (GPDH), an indicator of adipocyte formation, it is reported herein that AngII favors the appearance of GPDH-positive cells. In the presence of a cyclooxygenase inhibitor, this adipogenic effect is abolished, whereas that of (carba)prostacyclin, a stable analog of prostacyclin that bypasses this inhibition, appears unaltered.
Formal Description
Interaction-ID: 15998

gene/protein

Angiotensin II

increases_quantity of

gene/protein

GPD1

in white adipose tissue
Drugbank entries Show/Hide entries for GPD1
Comment Based upon in vivo and ex vivo experiments combined to immunocytochemical staining of glycerol-3-phosphate dehydrogenase (GPDH), an indicator of adipocyte formation, it is reported herein that AngII favors the appearance of GPDH-positive cells. In the presence of a cyclooxygenase inhibitor, this adipogenic effect is abolished, whereas that of (carba)prostacyclin, a stable analog of prostacyclin that bypasses this inhibition, appears unaltered.
Formal Description
Interaction-ID: 15999

gene/protein

Angiotensin II

increases_activity of

in white adipose tissue; via prostacyclin
Comment Based upon in vivo and ex vivo experiments combined to immunocytochemical staining of glycerol-3-phosphate dehydrogenase (GPDH), an indicator of adipocyte formation, it is reported herein that AngII favors the appearance of GPDH-positive cells. In the presence of a cyclooxygenase inhibitor, this adipogenic effect is abolished, whereas that of (carba)prostacyclin, a stable analog of prostacyclin that bypasses this inhibition, appears unaltered.
Formal Description
Interaction-ID: 16000

drug/chemical compound

Prostaglandin I2

affects_activity of

gene/protein

Angiotensin II

in white adipose tissue