General Information:

Id: 2,018 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Juan CC et al.(2005) Angiotensin II enhances insulin sensitivity in vitro and in vivo. Endocrinology 146: 2246-2254 [PMID: 15705782]

Interaction Information:

Comment AII had no effect on basal glucose uptake, but significantly potentiated insulin-stimulated glucose uptake; this effect was abolished by the AT1 antagonist, losartan.
Formal Description
Interaction-ID: 15989

gene/protein

Angiotensin II

increases_activity of

process

glucose import

in adipose tissue; if insulin-stimulated, via AGTR1
Comment Angiotensin II did not alter the insulin binding capacity of adipocytes, but increased insulin-stimulated tyrosine phosphorylation of the insulin receptor beta-subunit, Akt phosphorylation, and translocation of glucose transporter 4 to the plasma membrane.
Formal Description
Interaction-ID: 15992

gene/protein

Angiotensin II

increases_phosphorylation of

in adipose tissue; at Tyr residues, if insulin-stimulated
Comment Angiotensin II did not alter the insulin binding capacity of adipocytes, but increased insulin-stimulated tyrosine phosphorylation of the insulin receptor beta-subunit, Akt phosphorylation, and translocation of glucose transporter 4 to the plasma membrane.
Formal Description
Interaction-ID: 15993

gene/protein

Angiotensin II

increases_activity of

complex/PPI

Insulin receptor

in adipose tissue; if insulin-stimulated
Comment Angiotensin II did not alter the insulin binding capacity of adipocytes, but increased insulin-stimulated tyrosine phosphorylation of the insulin receptor beta-subunit, Akt phosphorylation, and translocation of glucose transporter 4 to the plasma membrane.
Formal Description
Interaction-ID: 15994

gene/protein

Angiotensin II

increases_phosphorylation of

gene/protein

AKT1

in adipose tissue; if insulin-stimulated
Drugbank entries Show/Hide entries for AKT1
Comment Angiotensin II did not alter the insulin binding capacity of adipocytes, but increased insulin-stimulated tyrosine phosphorylation of the insulin receptor beta-subunit, Akt phosphorylation, and translocation of glucose transporter 4 to the plasma membrane.
Formal Description
Interaction-ID: 15995

gene/protein

Angiotensin II

increases_transport of

gene/protein

SLC2A4

to the plasma membrane, in adipose tissue; if insulin-stimulated
Comment Angiotensin II (AII) potentiated insulin-stimulated glucose uptake through the AT1 receptor and by alteration of the intracellular signaling of insulin. Intraperitoneal injection of Sprague Dawley rats with AII increased insulin sensitivity in vivo.
Formal Description
Interaction-ID: 15996

gene/protein

Angiotensin II

increases_activity of

in adipose tissue; if insulin-stimulated
Comment Angiotensin II (AII) potentiated insulin-stimulated glucose uptake through the AT1 receptor and by alteration of the intracellular signaling of insulin. Intraperitoneal injection of Sprague Dawley rats with AII increased insulin sensitivity in vivo.
Formal Description
Interaction-ID: 15997

gene/protein

Angiotensin II

increases_activity of

in adipose tissue