General Information:

Id: 2,009 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
Ren-2 rat: transgenic hypertensive TG(mREN-2)27 rat
article
Reference: Blendea MC et al.(2005) Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression Am. J. Physiol. Endocrinol. Metab. 288: E353-E359 [PMID: 15494608]

Interaction Information:

Comment Insulin-mediated 2-deoxyglucose (2-DG) uptake was substantially lower in Ren-2 rat soleus muscle compared with controls. However, Ren-2 rats treated with valsartan or tempol exhibited a significant increase in insulin-mediated 2-DG uptake compared with untreated transgenic animals.
Formal Description
Interaction-ID: 15956

drug/chemical compound

Valsartan

increases_activity of

process

glucose import

in soleus muscle; in Ren-2 rats
Drugbank entries Show/Hide entries for Valsartan
Comment Insulin-mediated 2-deoxyglucose (2-DG) uptake was substantially lower in Ren-2 rat soleus muscle compared with controls. However, Ren-2 rats treated with valsartan or tempol exhibited a significant increase in insulin-mediated 2-DG uptake compared with untreated transgenic animals.
Formal Description
Interaction-ID: 15957

drug/chemical compound

Tempol

increases_activity of

process

glucose import

in soleus muscle; in Ren-2 rats