General Information:

Id: 2,009
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
Ren-2 rat: transgenic hypertensive TG(mREN-2)27 rat
article
Reference: Blendea MC et al.(2005) Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression Am. J. Physiol. Endocrinol. Metab. 288: E353-E359 [PMID: 15494608]

Interaction Information:

Comment Many tissues possess intrinsic angiotensinogen and angiotensin-converting enzyme activity, and thus are able to express a tissue renin-angiotensin system (RAS). A rodent model for tissue overexpression of RAS is the TG(mREN-2)27 (Ren-2) rat, a transgenic animal that harbors the mouse Ren-2 renin gene. This rodent model develops severe hypertension as a consequence of increases in the local RAS that culminates in elevated tissue ANG II levels.
Formal Description
Interaction-ID: 15947

gene/protein

REN

increases_activity of

process

renin-angiotensin system

in Ren-2 rats
Drugbank entries Show/Hide entries for REN
Comment Many tissues possess intrinsic angiotensinogen and angiotensin-converting enzyme activity, and thus are able to express a tissue renin-angiotensin system (RAS). A rodent model for tissue overexpression of RAS is the TG(mREN-2)27 (Ren-2) rat, a transgenic animal that harbors the mouse Ren-2 renin gene. This rodent model develops severe hypertension as a consequence of increases in the local RAS that culminates in elevated tissue ANG II levels.
Formal Description
Interaction-ID: 15948

gene/protein

REN

increases_activity of

phenotype

hypertension

in Ren-2 rats
Drugbank entries Show/Hide entries for REN
Comment Many tissues possess intrinsic angiotensinogen and angiotensin-converting enzyme activity, and thus are able to express a tissue renin-angiotensin system (RAS). A rodent model for tissue overexpression of RAS is the TG(mREN-2)27 (Ren-2) rat, a transgenic animal that harbors the mouse Ren-2 renin gene. This rodent model develops severe hypertension as a consequence of increases in the local RAS that culminates in elevated tissue ANG II levels.
Formal Description
Interaction-ID: 15950

gene/protein

REN

increases_quantity of

gene/protein

Angiotensin II

in Ren-2 rats
Drugbank entries Show/Hide entries for REN
Comment The insulin resistance index was significantly higher in the Ren-2 animals compared with Sprague-Dawley (SD) controls . Both the angiotensin II (ANG II) receptor blocker (ARB) valsartan and superoxide dismutase (SOD) mimetic, tempol, treatment normalized Ren-2 IR index.
Formal Description
Interaction-ID: 15951

gene/protein

REN

increases_activity of

disease

Insulin resistance

in Ren-2 rats
Drugbank entries Show/Hide entries for REN
Comment The insulin resistance index was significantly higher in the Ren-2 animals compared with Sprague-Dawley (SD) controls . Both the angiotensin II (ANG II) receptor blocker (ARB) valsartan and superoxide dismutase (SOD) mimetic, tempol, treatment normalized Ren-2 IR index.
Formal Description
Interaction-ID: 15952

drug/chemical compound

Valsartan

decreases_activity of

disease

Insulin resistance

in Ren-2 rats
Drugbank entries Show/Hide entries for Valsartan
Comment The insulin resistance index was significantly higher in the Ren-2 animals compared with Sprague-Dawley (SD) controls . Both the angiotensin II (ANG II) receptor blocker (ARB) valsartan and superoxide dismutase (SOD) mimetic, tempol, treatment normalized Ren-2 IR index.
Formal Description
Interaction-ID: 15953

drug/chemical compound

Tempol

decreases_activity of

disease

Insulin resistance

in Ren-2 rats
Comment Compared with SD controls, there was a significant increase in superoxide anion production in soleus muscles of Ren-2 rats. However, superoxide production was reduced in both valsartan- and tempol-treated Ren-2 rats.
Formal Description
Interaction-ID: 15954

drug/chemical compound

Valsartan

decreases_activity of

in soleus muscle; in Ren-2 rats
Drugbank entries Show/Hide entries for Valsartan
Comment Compared with SD controls, there was a significant increase in superoxide anion production in soleus muscles of Ren-2 rats. However, superoxide production was reduced in both valsartan- and tempol-treated Ren-2 rats.
Formal Description
Interaction-ID: 15955

drug/chemical compound

Tempol

decreases_activity of

in soleus muscle; in Ren-2 rats
Comment Insulin-mediated 2-deoxyglucose (2-DG) uptake was substantially lower in Ren-2 rat soleus muscle compared with controls. However, Ren-2 rats treated with valsartan or tempol exhibited a significant increase in insulin-mediated 2-DG uptake compared with untreated transgenic animals.
Formal Description
Interaction-ID: 15956

drug/chemical compound

Valsartan

increases_activity of

process

glucose import

in soleus muscle; in Ren-2 rats
Drugbank entries Show/Hide entries for Valsartan
Comment Insulin-mediated 2-deoxyglucose (2-DG) uptake was substantially lower in Ren-2 rat soleus muscle compared with controls. However, Ren-2 rats treated with valsartan or tempol exhibited a significant increase in insulin-mediated 2-DG uptake compared with untreated transgenic animals.
Formal Description
Interaction-ID: 15957

drug/chemical compound

Tempol

increases_activity of

process

glucose import

in soleus muscle; in Ren-2 rats
Comment Improvements in skeletal muscle insulin-dependent glucose uptake and whole body IR in rats overexpressing ANG II by ARB or SOD mimetic indicate that oxidative stress plays an important role in ANG II-mediated insulin resistance.
Formal Description
Interaction-ID: 15958

affects_activity of

gene/protein

Angiotensin II