General Information:

Id: 2,008 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
female
4-month-old Tg2576 mouse
article
Reference: Qin W et al.(2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 281 [PMID: 16751189]

Interaction Information:

Comment Calorie restriction increases SIRT1 expression and NAD+ levels in the brain of about 10-month-old Tg2576 mice.
Formal Description
Interaction-ID: 15946

environment

calorie restriction

increases_expression of

gene/protein

SIRT1

in the brain; of about 10-month-old Tg2576 mice
Comment SIRT1 expression promotes alpha-secretase activity and attenuates Abeta peptides generation in primary Tg2576 neuron cultures and CHO-APPswe cells.
Formal Description
Interaction-ID: 15970

gene/protein

SIRT1

increases_activity of

gene/protein

Alpha-secretase

Comment SIRT1 expression promotes alpha-secretase activity and attenuates Abeta peptides generation in primary Tg2576 neuron cultures and CHO-APPswe cells.
Formal Description
Interaction-ID: 15971

gene/protein

SIRT1

decreases_quantity of

gene/protein

Amyloid beta peptide