General Information:

Id: 2,007
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Monteiro JP and Cano MI(2011) SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview. Protein Pept. Lett. 18: 167-173 [PMID: 21121893]

Interaction Information:

Comment SIRT1 is a stress activated protein deacetylase that contributes to life-span extension by regulating different cell survival pathways, including replicative senescence, inflammation and resistance to hypoxic and heat stress.
Formal Description
Interaction-ID: 15918

affects_expression of

gene/protein

SIRT1

Comment Phosphorylation is the major mechanism controlling the level and function of SIRT1 required for normal cell cycle progression and cell survival under stress conditions.
Formal Description
Interaction-ID: 15922

process

phosphorylation

affects_activity of

gene/protein

SIRT1

Comment Phosphorylated SIRT1 deacetylates and coactivates HSF1.
Formal Description
Interaction-ID: 15924

gene/protein

SIRT1

decreases_acetylation of

gene/protein

HSF1

if SIRT1 is phosphorylated.
Comment Phosphorylated SIRT1 deacetylates and coactivates HSF1.
Formal Description
Interaction-ID: 15927

gene/protein

SIRT1

increases_activity of

gene/protein

HSF1

if SIRT1 is phosphorylated.
Comment Deacetylated HSF1 binds to the heat shock promoter element found upstream of genes encoding molecular chaperones.
Formal Description
Interaction-ID: 15930

gene/protein

HSF1

affects_expression of

gene/protein

Chaperone

when HSF1 is deacetylated; by binding to the heat shock promoter element found upstream of genes encoding molecular chaperones
Comment In a mouse model for Alzheimer's disease, SIRT1 deacetylase activity was also found activating the transcription of alpha-secretase, the enzyme responsible for inhibiting the formation of aggregates of neuronal beta-amyloid plaques.
Formal Description
Interaction-ID: 15942

gene/protein

SIRT1

affects_activity of

Comment In a mouse model for Alzheimer's disease, SIRT1 deacetylase activity was also found activating the transcription of alpha-secretase, the enzyme responsible for inhibiting the formation of aggregates of neuronal beta-amyloid plaques.
Formal Description
Interaction-ID: 15943

gene/protein

SIRT1

increases_expression of

gene/protein

Alpha-secretase

Comment Deacetylated HSF1 binds to the heat shock promoter element found upstream of genes encoding molecular chaperones.
Formal Description
Interaction-ID: 102287

gene/protein

HSF1

interacts (colocalizes) with

gene/protein

Chaperone

when HSF1 is deacetylated; by binding to the heat shock promoter element found upstream of genes encoding molecular chaperones