General Information:

Id: 2,006 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Bonda DJ et al.(2011) The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations Lancet Neurol 10: 275-279 [PMID: 21349442]

Interaction Information:

Comment SIRT1 increases alpha-secretase production and activity through activation of the alpha-secretase gene ADAM10.
Formal Description
Interaction-ID: 15914

gene/protein

SIRT1

increases_activity of

gene/protein

ADAM10