General Information:

Id: 2,006 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Bonda DJ et al.(2011) The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations Lancet Neurol 10: 275-279 [PMID: 21349442]

Interaction Information:

Comment SIRT1, one of the seven mammalian proteins of the sirtuin family of NAD+-dependent deacetylases, has recently been shown to attenuate amyloidogenic processing of amyloid-beta protein precursor (APP) in cell culture studies in vitro and in transgenic mouse models of Alzheimer's disease.
Formal Description
Interaction-ID: 15911

gene/protein

SIRT1

decreases_activity of

phenotype

amyloidosis

in cell culture studies in vitro and in transgenic mouse models of Alzheimer's disease