General Information:

Id: 2,006
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Bonda DJ et al.(2011) The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations Lancet Neurol 10: 275-279 [PMID: 21349442]

Interaction Information:

Comment SIRT1, one of the seven mammalian proteins of the sirtuin family of NAD+-dependent deacetylases, has recently been shown to attenuate amyloidogenic processing of amyloid-beta protein precursor (APP) in cell culture studies in vitro and in transgenic mouse models of Alzheimer's disease.
Formal Description
Interaction-ID: 15911

gene/protein

SIRT1

decreases_activity of

phenotype

amyloidosis

in cell culture studies in vitro and in transgenic mouse models of Alzheimer's disease
Comment SIRT1 increases alpha-secretase production and activity through activation of the alpha-secretase gene ADAM10.
Formal Description
Interaction-ID: 15913

gene/protein

ADAM10

affects_activity of

process

alpha-secretase pathway

Comment SIRT1 increases alpha-secretase production and activity through activation of the alpha-secretase gene ADAM10.
Formal Description
Interaction-ID: 15914

gene/protein

SIRT1

increases_activity of

gene/protein

ADAM10

Comment Because alpha-secretase is the enzyme responsible for the non-amyloidogenic cleavage of APP, upregulation of alpha-secretase shifts APP processing to reduce the pathological accumulation of the presumptive toxic Abeta species that results from beta-secretase and gamma-secretase activity.
Formal Description
Interaction-ID: 15915

gene/protein

Alpha-secretase

increases_processing of

gene/protein

APP

(=non-amyloidogenic cleavage of APP)
Drugbank entries Show/Hide entries for APP
Comment Because alpha-secretase is the enzyme responsible for the non-amyloidogenic cleavage of APP, upregulation of alpha-secretase shifts APP processing to reduce the pathological accumulation of the presumptive toxic Abeta species that results from beta-secretase and gamma-secretase activity.
Formal Description
Interaction-ID: 15916

gene/protein

Alpha-secretase

decreases_activity of

phenotype

amyloidosis