CIDeRGeneral Information:
| Id: | 2,002 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| BTO:0004578 vascular smooth muscle cell | |
| article | |
| Reference: | Zhang F et al.(2010) Different effects of angiotensin II and angiotensin-(1-7) on vascular smooth muscle cell proliferation and migration. PLoS ONE 5 [PMID: 20808802] |
Interaction Information:
| Comment | Ang-(1-7) inhibits Ang II-induced SMC proliferation. |
|
Formal Description Interaction-ID: 15886 |
gene/protein decreases_activity of gene/protein |
| Comment | Ang-(1-7) inhibits Ang II-induced SMC proliferation. |
|
Formal Description Interaction-ID: 15891 |
gene/protein increases_activity of process |
| Comment | Ang II increased SMC migration, whereas Ang-(1-7) alone had no effect. However, cells treated with both Ang II and Ang-(1-7) had significant lower rate of migration compared with cells treated with Ang II alone, suggesting that Ang-(1-7) inhibited the stimulating effect of Ang II on SMC migration. |
|
Formal Description Interaction-ID: 15892 |
gene/protein increases_activity of process |
| Comment | The ERK1/2 signaling pathway plays a major role in Ang II-induced SMC proliferation and migration. Ang II treatment stimulated phosphorylation of ERK1/2 and that this effect was significantly inhibited in the presence of Ang-(1-7). |
|
Formal Description Interaction-ID: 15897 |
gene/protein increases_phosphorylation of gene/protein MAPK3/1 |