General Information:

Id: 1,989 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Myocardial infarction - [OMIM]
Nephropathy, diabetic
Neuropathy, diabetic
Retinopathy, diabetic
Stroke, ischemic - [OMIM]
Mammalia
review
Reference: Lardizabal JA and Deedwania PC(2010) The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus Curr Cardiol Rep 12: 464-471 [PMID: 20809236]

Interaction Information:

Comment In patients with IGT, both early and late phases of insulin secretory responses are abnormal, leading to prolonged hyperglycemia after a glucose load. In those with isolated IFG, there is reduction in the early phase of insulin secretory response, which causes fasting hyperglycemia; however, the late phase response is preserved, which allows the normalization of blood sugar levels after a glucose load.
Formal Description
Interaction-ID: 15638

affects_activity of

in pancreas; in early and late phase
Comment In patients with IGT, both early and late phases of insulin secretory responses are abnormal, leading to prolonged hyperglycemia after a glucose load. In those with isolated IFG, there is reduction in the early phase of insulin secretory response, which causes fasting hyperglycemia; however, the late phase response is preserved, which allows the normalization of blood sugar levels after a glucose load.
Formal Description
Interaction-ID: 15640

phenotype

hyperglycemia

affects_activity of

in pancreas; after fasting, in early phase, not in late phase
Comment The protection afforded by ARBs against the deleterious effects of inflammatory and oxidative stress was associated with increased beta-cell mass, augmented insulin secretion, and improved glucose tolerance. Furthermore, ARB therapy was also shown to prevent the loss of endothelial cells and reduce fibrosis in and around the islets.
Formal Description
Interaction-ID: 15692

drug/chemical compound

Angiotensin II type 1 receptor blocker

decreases_activity of