General Information:

Id: 1,989 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Myocardial infarction - [OMIM]
Nephropathy, diabetic
Neuropathy, diabetic
Retinopathy, diabetic
Stroke, ischemic - [OMIM]
Mammalia
review
Reference: Lardizabal JA and Deedwania PC(2010) The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus Curr Cardiol Rep 12: 464-471 [PMID: 20809236]

Interaction Information:

Comment ARBs, conversely, are able to attenuate the negative effects of AT II on cellular insulin signaling by specifically inhibiting the AT II type 1 receptors. The ARB-related improvement in insulin-stimulated glucose uptake has been documented not only in muscle and hepatic cells, but in adipose tissue as well.
Formal Description
Interaction-ID: 15683

drug/chemical compound

Angiotensin II type 1 receptor blocker

increases_activity of

process

glucose import

in muscle, in liver, in adipose tissue; if insulin-stimulated