General Information:

Id: 1,988
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
isolated pancreatic islets
article
Reference: Lupi R et al.(2006) The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets. Eur. J. Endocrinol. 154: 355-361 [PMID: 16452552]

Interaction Information:

Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15611

drug/chemical compound

Glucose

increases_expression of

gene/protein

AGT

in pancreas, in pancreatic islets
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15612

drug/chemical compound

Glucose

increases_expression of

gene/protein

ACE

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for ACE
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15613

drug/chemical compound

Glucose

increases_expression of

gene/protein

AGTR1

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for AGTR1
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15614

drug/chemical compound

Zofenopril

decreases_activity of

gene/protein

ACE

Drugbank entries Show/Hide entries for ACE
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15615

drug/chemical compound

Enalaprilat

decreases_activity of

gene/protein

ACE

Drugbank entries Show/Hide entries for ACE
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15616

drug/chemical compound

Zofenopril

NOT increases_expression of

gene/protein

AGT

in pancreas, in pancreatic islets; after glucose stimulation
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15617

drug/chemical compound

Zofenopril

NOT increases_expression of

gene/protein

ACE

in pancreas, in pancreatic islets; after glucose stimulation
Drugbank entries Show/Hide entries for ACE
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15618

drug/chemical compound

Zofenopril

NOT increases_expression of

gene/protein

AGTR1

in pancreas, in pancreatic islets; after glucose stimulation
Drugbank entries Show/Hide entries for AGTR1
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15619

drug/chemical compound

Enalaprilat

NOT increases_expression of

gene/protein

AGT

in pancreas, in pancreatic islets; after glucose stimulation
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15620

drug/chemical compound

Enalaprilat

NOT increases_expression of

gene/protein

ACE

in pancreas, in pancreatic islets; after glucose stimulation
Drugbank entries Show/Hide entries for ACE
Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15621

drug/chemical compound

Enalaprilat

NOT increases_expression of

gene/protein

AGTR1

in pancreas, in pancreatic islets; after glucose stimulation
Drugbank entries Show/Hide entries for AGTR1
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15622

phenotype

hyperglycemia

decreases_activity of

in pancreas, in pancreatic islets
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15623

phenotype

hyperglycemia

increases_activity of

in pancreas, in pancreatic islets
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15624

phenotype

hyperglycemia

increases_quantity of

drug/chemical compound

3-Nitrotyrosine

in pancreas, in pancreatic islets
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15625

phenotype

hyperglycemia

increases_expression of

gene/protein

PRKCB

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for PRKCB
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15626

phenotype

hyperglycemia

increases_quantity of

complex/PPI

NADPH oxidase complex

in pancreas, in pancreatic islets
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15627

drug/chemical compound

Enalaprilat

affects_activity of

in pancreas, in pancreatic islets
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15628

drug/chemical compound

Enalaprilat

affects_activity of

in pancreas, in pancreatic islets
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15629

drug/chemical compound

Zofenopril

affects_activity of

in pancreas, in pancreatic islets
Comment Preculture of human islets in high glucose determined a marked reduction in insulin secretion which was associated with enhanced oxidative stress, as shown by increased nitrotyrosine concentrations, and enhanced expression of protein kinase C beta and NADPH oxidase. The presence of either of the ACE inhibitors counteracted several of the deleterious effects of high glucose exposure, including reduction of insulin secretion and increased oxidative stress; zofenoprilat showed significantly more marked effects.
Formal Description
Interaction-ID: 15630

drug/chemical compound

Zofenopril

affects_activity of

in pancreas, in pancreatic islets
Comment RAS molecules are present in human islets and their expression is sensitive to glucose concentration.
Formal Description
Interaction-ID: 15631

phenotype

hyperglycemia

affects_activity of

process

renin-angiotensin system

in pancreas, in pancreatic islets
Comment ACE inhibitors, and in particular zofenoprilat, protect human islets from glucotoxicity and the effects of ACE inhibition are associated with decreased oxidative stress.
Formal Description
Interaction-ID: 15632

drug/chemical compound

ACE inhibitor

affects_activity of

in pancreas, in pancreatic islets