General Information:

Id: 1,987 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
female
primary cultured human preadipocytes
article
Reference: Janke J et al.(2002) Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors. Diabetes 51: 1699-1707 [PMID: 12031955]

Interaction Information:

Comment Incubation with Ang II or AGT resulted in a dose-dependent inhibition of adipogenic differentiation, despite concomitant stimulation with the differentiation cocktail (insulin plus hydrocortisone plus T3).
Formal Description
Interaction-ID: 15597

gene/protein

Angiotensin II

decreases_activity of

process

fat cell differentiation

in adipose tissue
Comment In contrast to stimulation with Ang II, AT1 receptor blockade with irbesartan increased lipid accumulation. Increased lipid accumulation was attributable to both an increased number of differentiated cells and an increase in intracytoplasmic lipid accumulation.
Formal Description
Interaction-ID: 15599

gene/protein

Angiotensin II

decreases_quantity of

drug/chemical compound

Lipid

in adipose tissue
Comment Inhibition of adipogenic differentiation by Ang II and stimulation by AT1 receptor blockade with irbesartan was also accompanied by a respective decrease or increase in expression of the adipogenic marker genes PPAR-gamma and FAS.
Formal Description
Interaction-ID: 15602

gene/protein

Angiotensin II

decreases_expression of

gene/protein

PPARG

in adipose tissue
Drugbank entries Show/Hide entries for PPARG
Comment Inhibition of adipogenic differentiation by Ang II and stimulation by AT1 receptor blockade with irbesartan was also accompanied by a respective decrease or increase in expression of the adipogenic marker genes PPAR-gamma and FAS.
Formal Description
Interaction-ID: 15603

gene/protein

Angiotensin II

decreases_expression of

gene/protein

FASN

in adipose tissue
Drugbank entries Show/Hide entries for FASN