General Information:

Id: 1,978 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Velloso LA et al.(1996) Cross-talk between the insulin and angiotensin signaling systems Proc. Natl. Acad. Sci. U.S.A. 93 [PMID: 8901609]

Interaction Information:

Comment Following injection of insulin and/or angiotensin II (All) into rats, the authors find that there is a rapid tyrosine phosphorylation of the major insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) in the heart.
Formal Description
Interaction-ID: 15518

gene/protein

Angiotensin II

increases_phosphorylation of

gene/protein

IRS1

in cardiac muscle; at Tyr residues
Drugbank entries Show/Hide entries for IRS1
Comment Following injection of insulin and/or angiotensin II (All) into rats, the authors find that there is a rapid tyrosine phosphorylation of the major insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) in the heart.
Formal Description
Interaction-ID: 15519

gene/protein

Angiotensin II

increases_phosphorylation of

gene/protein

IRS2

in cardiac muscle; at Tyr residues
Comment The phosphorylation of IRS1 and IRS2 following the injection of angiotensin II appears to involve JAK2 tyrosine kinase, which associates with the AT1 receptor and IRS-1/IRS-2 after AII stimulation.
Formal Description
Interaction-ID: 15521

gene/protein

Angiotensin II

affects_activity of

gene/protein

JAK2

Drugbank entries Show/Hide entries for JAK2
Comment Following AII injection there was a dose-dependent inhibition of PI 3-kinase activity associated with IRS-1 and IRS-2, with maximal decreases of 55% and 60% below basal values after injection of as little as 200 pmol of AII.
Formal Description
Interaction-ID: 15525

gene/protein

Angiotensin II

decreases_activity of

complex/PPI

Phosphatidylinositol 3-kinase

in cardiac muscle