General Information:

Id: 1,963 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Koves TR et al.(2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7: 45-56 [PMID: 18177724]

Interaction Information:

Comment In cultured L6 myotubes, lipid-induced insulin resistance was prevented by manipulations that restrict fatty acid uptake into mitochondria. Insulin resistance in L6 myocytes requires beta-oxidation.
Formal Description
Interaction-ID: 15411

increases_activity of


Insulin resistance

in skeletal muscle