General Information:

Id: 1,963 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Koves TR et al.(2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7: 45-56 [PMID: 18177724]

Interaction Information:

Comment Consistent with the serum profile, a marked accumulation of fatty acylcarnitine species in muscles from HF-fed rats was observed. Whereas SC-fed rats lowered most muscle fatty acylcarnitines during the transition from the fasted to the fed state, HF-fed animals exhibited little or no change. Thus, during fasted conditions, the import of fatty acids into muscle mitochondria appears to exceed metabolic demand. Feeding relieved the surplus, but only in the SC-fed group, suggesting that mitochondria from obese animals are unable to appropriately adjust fatty acid influx in response to nutritional status.
Formal Description
Interaction-ID: 15402


high-fat diet

increases_activity of

in skeletal muscle