General Information:

Id: 1,963 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Koves TR et al.(2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7: 45-56 [PMID: 18177724]

Interaction Information:

Comment In response to overnight fasting, in serum most lipid-derived acylcarnitines increased, whereas the amino acid intermediates decreased. Consistent with the fasting-induced rise in circulating NEFA, this profile implies a metabolic switch favoring higher rates of beta-oxidation and diminished degradation of amino acids.
Formal Description
Interaction-ID: 15399



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