CIDeRGeneral Information:
| Id: | 1,963 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| male | |
| article | |
| Reference: | Koves TR et al.(2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7: 45-56 [PMID: 18177724] |
Interaction Information:
| Comment | In response to overnight fasting, in serum most lipid-derived acylcarnitines increased, whereas the amino acid intermediates decreased. Consistent with the fasting-induced rise in circulating NEFA, this profile implies a metabolic switch favoring higher rates of beta-oxidation and diminished degradation of amino acids. |
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Formal Description Interaction-ID: 15399 |
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| Comment | Under fasting conditions, serum acylcarnitines were similar between the two diet groups. Conversely, serum samples collected in the fed state revealed higher levels of several fatty acid-derived species and reduced levels of C3, C4, and C5 in HF-fed animals compared to SC-fed animals. |
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Formal Description Interaction-ID: 15401 |
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| Comment | Consistent with the serum profile, a marked accumulation of fatty acylcarnitine species in muscles from HF-fed rats was observed. Whereas SC-fed rats lowered most muscle fatty acylcarnitines during the transition from the fasted to the fed state, HF-fed animals exhibited little or no change. Thus, during fasted conditions, the import of fatty acids into muscle mitochondria appears to exceed metabolic demand. Feeding relieved the surplus, but only in the SC-fed group, suggesting that mitochondria from obese animals are unable to appropriately adjust fatty acid influx in response to nutritional status. |
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Formal Description Interaction-ID: 15402 |
environment high-fat diet increases_activity of process |
| Comment | In contrast to skeletal muscle, liver acylcarnitines were not elevated in HF-fed animals compared to SC-fed animals. |
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Formal Description Interaction-ID: 15403 |
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| Comment | In cultured L6 myotubes, lipid-induced insulin resistance was prevented by manipulations that restrict fatty acid uptake into mitochondria. Insulin resistance in L6 myocytes requires beta-oxidation. |
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Formal Description Interaction-ID: 15411 |
process increases_activity of disease Insulin resistance |