General Information:

Id: 1,962 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Dresner A et al.(1999) Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity J. Clin. Invest. 103: 253-259 [PMID: 9916137]

Interaction Information:

Comment Increased concentrations of plasma FFA induce insulin resistance in humans through inhibition of glucose transport activity; this may be a consequence of decreased IRS-1-associated PI 3-kinase activity.
Formal Description
Interaction-ID: 15300

increases_activity of

process

glucose import

in skeletal muscle