General Information:

Id: 1,957 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Gibson GE et al.(2008) Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimers disease Ann. N. Y. Acad. Sci. 1147: 221-232 [PMID: 19076444]

Interaction Information:

Comment KGDHC (alpha-ketoglutaric acid dehydrogenase complex) is inactivated by a variety of oxidants, including peroxynitrite, NO, hydroxynonenal, H2O2, chloroamine, and sodium hypochlorite. H2O2 diminishes KGDHC activity in synaptosomes, fibroblasts, and N2a cells.
Formal Description
Interaction-ID: 15303

drug/chemical compound


decreases_activity of


Alpha-ketoglutarate dehydrogenase complex

in synaptosomes, fibroblasts, and N2a cells