General Information:

Id: 1,957 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Gibson GE et al.(2008) Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimers disease Ann. N. Y. Acad. Sci. 1147: 221-232 [PMID: 19076444]

Interaction Information:

Comment KGDHC (alpha-ketoglutaric acid dehydrogenase complex) is inactivated by a variety of oxidants, including peroxynitrite, NO, hydroxynonenal, H2O2, chloroamine, and sodium hypochlorite. H2O2 diminishes KGDHC activity in synaptosomes, fibroblasts, and N2a cells.
Formal Description
Interaction-ID: 15303

drug/chemical compound

H2O2

decreases_activity of

complex/PPI

Alpha-ketoglutarate dehydrogenase complex

in synaptosomes, fibroblasts, and N2a cells
Comment The H2O2-induced increase in ROS and cell death is greater in cells with diminished E2k than in controls.
Formal Description
Interaction-ID: 15325

drug/chemical compound

H2O2

affects_quantity of

drug/chemical compound

Reactive oxygen species

Comment The H2O2-induced increase in ROS and cell death is greater in cells with diminished E2k than in controls.
Formal Description
Interaction-ID: 15326

drug/chemical compound

H2O2

affects_activity of

process

neuron death

Comment Under reducing conditions KGDHC is the primary source of H2O2 in mitochondria.
Formal Description
Interaction-ID: 15494

complex/PPI

Alpha-ketoglutarate dehydrogenase complex

affects_quantity of

drug/chemical compound

H2O2

in mitochondria