General Information:

Id: 1,957 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Gibson GE et al.(2008) Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimers disease Ann. N. Y. Acad. Sci. 1147: 221-232 [PMID: 19076444]

Interaction Information:

Comment Sources of oxidative stress in the brain are free radicals or reactive oxygen species (ROS) include superoxide, hydroxyl radical, nitric oxide, peroxynitrite, and hydroperoxyl radicals.
Formal Description
Interaction-ID: 15189

drug/chemical compound

NO

increases_activity of

Comment KGDHC (alpha-ketoglutaric acid dehydrogenase complex) is inactivated by a variety of oxidants, including peroxynitrite, NO, hydroxynonenal, H2O2, chloroamine, and sodium hypochlorite.
Formal Description
Interaction-ID: 15299

drug/chemical compound

NO

decreases_activity of

complex/PPI

Alpha-ketoglutarate dehydrogenase complex