General Information:

Id: 1,953 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse
article
Reference: Chiba T et al.(2009) Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Mol. Psychiatry 14: 206-222 [PMID: 18813209]

Interaction Information:

Comment p-STAT3 levels in hippocampal neurons age-dependently decreased in both AD model mice and AD patients.
Formal Description
Interaction-ID: 15137

process

aging

decreases_quantity of

protein modification

STAT3-phos

in hippocampal neurons; in AD mouse model and AD patients