General Information:

Id: 1,951 (click here to show other Interactions for entry)
Diseases: Epilepsy
Status epilepticus
Rattus norvegicus
BTO:0000601 hippocampus
article
Reference: Shin EJ et al.(2009) Protection against kainate neurotoxicity by ginsenosides: attenuation of convulsive behavior, mitochondrial dysfunction, and oxidative stress J. Neurosci. Res. 87: 710-722 [PMID: 18816793]

Interaction Information:

Comment The KA-induced seizures contributed to mitochondrial oxidative stress (increased lipid peroxidation and protein oxidation, decreased the reduced glutathione/oxidized glutathione (GSH/GSSG) ratio) followed by hippocampal degeneratio.
Formal Description
Interaction-ID: 15091

decreases_quantity of

drug/chemical compound

Glutathione

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Comment The ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Ro, Ra1) attenuate KA-induced glutathione oxidation in the homogenate and mitochondrial fraction of the rat hippocampus.
Formal Description
Interaction-ID: 15142

drug/chemical compound

Ginsenoside Re

increases_quantity of

drug/chemical compound

Glutathione

if seizures were induced by kainic acid
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Comment The ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Ro, Ra1) attenuate KA-induced glutathione oxidation in the homogenate and mitochondrial fraction of the rat hippocampus.
Formal Description
Interaction-ID: 15195

drug/chemical compound

Ginsenoside Rf

increases_quantity of

drug/chemical compound

Glutathione

if seizures were induced by kainic acid
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Comment The ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Ro, Ra1) attenuate KA-induced glutathione oxidation in the homogenate and mitochondrial fraction of the rat hippocampus.
Formal Description
Interaction-ID: 15196

drug/chemical compound

Ginsenoside Rg1

increases_quantity of

drug/chemical compound

Glutathione

if seizures were induced by kainic acid
Drugbank entries Show/Hide entries for
Comment The ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Ro, Ra1) attenuate KA-induced glutathione oxidation in the homogenate and mitochondrial fraction of the rat hippocampus.
Formal Description
Interaction-ID: 15205

drug/chemical compound

Ginsenoside Rb1

increases_quantity of

drug/chemical compound

Glutathione

if seizures were induced by kainic acid
Drugbank entries Show/Hide entries for
Comment The ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Ro, Ra1) attenuate KA-induced glutathione oxidation in the homogenate and mitochondrial fraction of the rat hippocampus.
Formal Description
Interaction-ID: 15206

drug/chemical compound

Ginsenoside Rb2

increases_quantity of

drug/chemical compound

Glutathione

if seizures were induced by kainic acid
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Comment The ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Ro, Ra1) attenuate KA-induced glutathione oxidation in the homogenate and mitochondrial fraction of the rat hippocampus.
Formal Description
Interaction-ID: 15208

drug/chemical compound

Ginsenoside Rc

increases_quantity of

drug/chemical compound

Glutathione

if seizures were induced by kainic acid
Drugbank entries Show/Hide entries for
Comment The ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Ro, Ra1) attenuate KA-induced glutathione oxidation in the homogenate and mitochondrial fraction of the rat hippocampus.
Formal Description
Interaction-ID: 15209

drug/chemical compound

Ginsenoside Rd

increases_quantity of

drug/chemical compound

Glutathione

if seizures were induced by kainic acid
Drugbank entries Show/Hide entries for