General Information:

Id: 1,949 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
BTO:0000011 3T3-L1 cell
article
Reference: Gonzales AM and Orlando RA(2008) Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr Metab (Lond) 5: 17 [PMID: 18549505]

Interaction Information:

Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15068

drug/chemical compound

Resveratrol

decreases_activity of

complex/PPI

NF-kappaB complex

in adipose tissue
Drugbank entries Show/Hide entries for Resveratrol
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15070

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

TNF

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or TNF
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15074

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

IL1B

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or IL1B
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15077

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

IL6

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or IL6
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15079

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

PTGS2

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or PTGS2
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15082

drug/chemical compound

Resveratrol

decreases_quantity of

drug/chemical compound

Prostaglandin E2

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol
Comment Curcumin and resveratrol are able to inhibit TNFalpha-activated NF-kappaB signaling in adipocytes and as a result significantly reduce cytokine expression.
Formal Description
Interaction-ID: 15086

drug/chemical compound

Resveratrol

decreases_activity of

in adipose tissue
Drugbank entries Show/Hide entries for Resveratrol